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  "Description": "Application of 'RaceID' allows inference of cell types and\nprediction of lineage trees by the 'StemID2' algorithm (Herman,\nJ.S., Sagar, Grun D. (2018) <DOI:10.1038/nmeth.4662>). 'VarID2'\nis part of this package and allows quantification of biological\ngene expression noise at single-cell resolution\n(Rosales-Alvarez, R.E., Rettkowski, J., Herman, J.S., Dumbovic,\nG., Cabezas-Wallscheid, N., Grun, D. (2023)\n<DOI:10.1186/s13059-023-02974-1>).",
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      "page": "RaceID-package",
      "title": "Identification of Cell Types, Inference of Lineage Trees, and Prediction of Noise Dynamics from Single-Cell RNA-Seq Data",
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      "title": "Function for calculating the total variance fit",
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      "title": "Computes Medoids from a Clustering Partition",
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      "title": "Computing P-values for Link Significance",
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      "title": "Function for extracting genes with differential biological variability in a cluster",
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      "title": "Function for fitting a negative binomial noise model of technical and biological variability",
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    },
    {
      "page": "fractDotPlot",
      "title": "Dotplot of gene expression across clusters or samples",
      "topics": [
        "fractDotPlot"
      ]
    },
    {
      "page": "getExpData",
      "title": "Function for extracting a filtered expression matrix from a 'RaceID' 'SCseq' object",
      "topics": [
        "getExpData"
      ]
    },
    {
      "page": "getfdata",
      "title": "Extracting filtered expression data",
      "topics": [
        "getfdata"
      ]
    },
    {
      "page": "getFilteredCounts",
      "title": "Function for filtering count data",
      "topics": [
        "getFilteredCounts"
      ]
    },
    {
      "page": "getNode",
      "title": "Extract all genes for a module in a FateID self-orgaizing map",
      "topics": [
        "getNode"
      ]
    },
    {
      "page": "getproj",
      "title": "Extract Projections of all Cells from a Cluster",
      "topics": [
        "getproj"
      ]
    },
    {
      "page": "graphCluster",
      "title": "Function for infering clustering of the pruned k nearest neighbour graph",
      "topics": [
        "graphCluster"
      ]
    },
    {
      "page": "imputeexp",
      "title": "Imputed expression matrix",
      "topics": [
        "imputeexp"
      ]
    },
    {
      "page": "inspectKNN",
      "title": "Function for inspecting pruned k-nearest neighbourhoods",
      "topics": [
        "inspectKNN"
      ]
    },
    {
      "page": "intestinalData",
      "title": "Single-cell transcriptome data of intestinal epithelial cells",
      "topics": [
        "intestinalData"
      ]
    },
    {
      "page": "intestinalDataSmall",
      "title": "Single-cell transcriptome data of intestinal epithelial cells",
      "topics": [
        "intestinalDataSmall"
      ]
    },
    {
      "page": "lineagegraph",
      "title": "Inference of a Lineage Graph",
      "topics": [
        "lineagegraph"
      ]
    },
    {
      "page": "Ltree",
      "title": "The Ltree Class",
      "topics": [
        "Ltree",
        "Ltree-class"
      ]
    },
    {
      "page": "maxNoisyGenes",
      "title": "Function for extracting genes maximal variability",
      "topics": [
        "maxNoisyGenes"
      ]
    },
    {
      "page": "maxNoisyGenesTB",
      "title": "Function for extracting genes maximal variability",
      "topics": [
        "maxNoisyGenesTB"
      ]
    },
    {
      "page": "noiseBaseFit",
      "title": "Function for computing a fit to the baseline of gene expression variability",
      "topics": [
        "noiseBaseFit"
      ]
    },
    {
      "page": "plotB",
      "title": "Boxplots for features across clusters",
      "topics": [
        "plotB"
      ]
    },
    {
      "page": "plotbackground",
      "title": "Plot Background Model",
      "topics": [
        "plotbackground"
      ]
    },
    {
      "page": "plotBackVar",
      "title": "Function for plottinhg the background model of gene expression variability",
      "topics": [
        "plotBackVar"
      ]
    },
    {
      "page": "plotdiffgenes",
      "title": "Barplot of differentially expressed genes",
      "topics": [
        "plotdiffgenes"
      ]
    },
    {
      "page": "plotdiffgenesnb",
      "title": "Function for plotting differentially expressed genes",
      "topics": [
        "plotdiffgenesnb"
      ]
    },
    {
      "page": "plotDiffNoise",
      "title": "Function for plotting differentially variable genes",
      "topics": [
        "plotDiffNoise"
      ]
    },
    {
      "page": "plotdimsat",
      "title": "Plotting the Saturation of Explained Variance",
      "topics": [
        "plotdimsat"
      ]
    },
    {
      "page": "plotdistanceratio",
      "title": "Histogram of Cell-to-Cell Distances in Real versus Embedded Space",
      "topics": [
        "plotdistanceratio"
      ]
    },
    {
      "page": "plotexpmap",
      "title": "Highlighting gene expression in a dimensional reduction representation",
      "topics": [
        "plotexpmap"
      ]
    },
    {
      "page": "plotExpNoise",
      "title": "Noise-expression scatter plot",
      "topics": [
        "plotExpNoise"
      ]
    },
    {
      "page": "plotfeatmap",
      "title": "Highlighting feature values in a dimensional reduction representation",
      "topics": [
        "plotfeatmap"
      ]
    },
    {
      "page": "plotgraph",
      "title": "StemID2 Lineage Graph",
      "topics": [
        "plotgraph"
      ]
    },
    {
      "page": "plotjaccard",
      "title": "Plot Jaccard Similarities",
      "topics": [
        "plotjaccard"
      ]
    },
    {
      "page": "plotlabelsmap",
      "title": "Plot labels in a dimensional reduction representation",
      "topics": [
        "plotlabelsmap"
      ]
    },
    {
      "page": "plotlinkpv",
      "title": "Heatmap of Link P-values",
      "topics": [
        "plotlinkpv"
      ]
    },
    {
      "page": "plotlinkscore",
      "title": "Heatmap of Link Scores",
      "topics": [
        "plotlinkscore"
      ]
    },
    {
      "page": "plotmap",
      "title": "Plotting a dimensional reduction representation",
      "topics": [
        "plotmap"
      ]
    },
    {
      "page": "plotmarkergenes",
      "title": "Plotting a Heatmap of Marker Gene Expression",
      "topics": [
        "plotmarkergenes"
      ]
    },
    {
      "page": "plotMV",
      "title": "Plot of Mean-Variance dependence and various fits",
      "topics": [
        "plotMV"
      ]
    },
    {
      "page": "plotNoiseModel",
      "title": "Function for plotting the baseline model of gene expression variability",
      "topics": [
        "plotNoiseModel"
      ]
    },
    {
      "page": "plotoutlierprobs",
      "title": "Plot Outlier Probabilities",
      "topics": [
        "plotoutlierprobs"
      ]
    },
    {
      "page": "plotPC",
      "title": "Function to plot the selected number of principal components",
      "topics": [
        "plotPC"
      ]
    },
    {
      "page": "plotPearsonRes",
      "title": "Function for plotting the variance of Pearson residuals",
      "topics": [
        "plotPearsonRes"
      ]
    },
    {
      "page": "plotPP",
      "title": "Plotting function for posterior checks",
      "topics": [
        "plotPP"
      ]
    },
    {
      "page": "plotPT",
      "title": "Plotting pseudo-time in dimensional reduction representation",
      "topics": [
        "plotPT"
      ]
    },
    {
      "page": "plotQQ",
      "title": "Scatter plot of two noise-related quantaties of local pruned k-nearest neighbourhoods",
      "topics": [
        "plotQQ"
      ]
    },
    {
      "page": "plotQuantMap",
      "title": "Plotting noise-related quantaties of local pruned k-nearest neighbourhoods",
      "topics": [
        "plotQuantMap"
      ]
    },
    {
      "page": "plotRegNB",
      "title": "Function for plotting negative binomial regression",
      "topics": [
        "plotRegNB"
      ]
    },
    {
      "page": "plotsaturation",
      "title": "Plot Saturation of Within-Cluster Dispersion",
      "topics": [
        "plotsaturation"
      ]
    },
    {
      "page": "plotsensitivity",
      "title": "Plot Sensitivity",
      "topics": [
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      ]
    },
    {
      "page": "plotsilhouette",
      "title": "Plot Cluster Silhouette",
      "topics": [
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      ]
    },
    {
      "page": "plotspantree",
      "title": "Minimum Spanning Tree of RaceID3 clusters",
      "topics": [
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    },
    {
      "page": "plotsymbolsmap",
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      "topics": [
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    },
    {
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      "topics": [
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      ]
    },
    {
      "page": "plotUMINoise",
      "title": "Plotting noise dependence on total UMI count",
      "topics": [
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      ]
    },
    {
      "page": "postfntb",
      "title": "Posterior probability",
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      ]
    },
    {
      "page": "priorfn",
      "title": "Prior function for maximum a posterior inference",
      "topics": [
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      ]
    },
    {
      "page": "projback",
      "title": "Compute Cell Projections for Randomized Background Distribution",
      "topics": [
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      ]
    },
    {
      "page": "projcells",
      "title": "Compute transcriptome entropy of each cell",
      "topics": [
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      ]
    },
    {
      "page": "projenrichment",
      "title": "Enrichment of cells on inter-cluster links",
      "topics": [
        "projenrichment"
      ]
    },
    {
      "page": "pruneKnn",
      "title": "Function inferring a pruned knn matrix",
      "topics": [
        "pruneKnn"
      ]
    },
    {
      "page": "pseudoTime",
      "title": "Extract pseudo-time order of cells along a trajectory",
      "topics": [
        "pseudoTime"
      ]
    },
    {
      "page": "quantKnn",
      "title": "Noise-related quantaties of local pruned k-nearest neighbourhoods",
      "topics": [
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      ]
    },
    {
      "page": "rcpp_hello_world",
      "title": "Simple function using Rcpp",
      "topics": [
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      ]
    },
    {
      "page": "rfcorrect",
      "title": "Random Forests-based Reclassification",
      "topics": [
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      ]
    },
    {
      "page": "SCseq",
      "title": "The SCseq Class",
      "topics": [
        "SCseq",
        "SCseq-class"
      ]
    },
    {
      "page": "Seurat2SCseq",
      "title": "Converting a Seurat object to a RaceID/VarID object",
      "topics": [
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      ]
    },
    {
      "page": "testPrior",
      "title": "Posterior check of the model",
      "topics": [
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      ]
    },
    {
      "page": "transitionProbs",
      "title": "Function for the computation of transition probabilities between clusters",
      "topics": [
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      ]
    },
    {
      "page": "updateSC",
      "title": "Function for updating a RaceID SCseq object with VarID results",
      "topics": [
        "updateSC"
      ]
    },
    {
      "page": "varRegression",
      "title": "Linear Regression of Sources of Variability",
      "topics": [
        "varRegression"
      ]
    },
    {
      "page": "violinMarkerPlot",
      "title": "Violin plot of marker gene expression or noise",
      "topics": [
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      ]
    }
  ],
  "_rundeps": [
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  "_sysdeps": [
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      "package": "libstdc++6",
      "source": "gcc",
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      "name": "c++",
      "homepage": "http://gcc.gnu.org/",
      "description": "GNU Standard C++ Library v3"
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  ],
  "_vignettes": [
    {
      "source": "RaceID.Rmd",
      "filename": "RaceID.html",
      "title": "RaceID/StemID/VarID reference manual",
      "author": "Dominic Grun",
      "engine": "knitr::rmarkdown",
      "headings": [
        "Prerequisites",
        "RaceID",
        "Example RaceID analysis",
        "StemID",
        "Example StemID analysis: projection mode",
        "Example StemID analysis: nearest-neighbour mode",
        "RaceID/StemID Options",
        "Batch effect removal",
        "Imputing of gene expression",
        "Removing variability by regression",
        "Prior dimensional reduction and removal of variability by PCA/ICA",
        "Inferring stable clusters by random forests analysis",
        "Parameters: Large Datasets",
        "Inspecting pseudo-temporal gene expression changes",
        "VarID2",
        "Example VarID2 analysis",
        "Removing batch effects and other confounding factors with VarID2",
        "Integrating Seurat with VarID2/RaceID3",
        "FAQ",
        "References"
      ],
      "created": "2018-07-27 12:40:02",
      "modified": "2024-04-04 02:33:54",
      "commits": 18
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